The Results
American Journal of Veterinary Research
Key Findings SASHAS EQ Horse Trials IN-VIVO:
- Intra-articular injection of IL-1 caused increased concentrations of synovial fluid PGE2 and GAG consistent with inflammation and cartilage degradation associated with arthritis
- Feeding of Sashas EQ inhibited the increase of PGE2 (54.6% decrease) and GAG induced by the intra-articular injection of IL-1 highlighting Sashas EQ anti-inflammatory and chondroprotective properties as also demonstrated in in-vitro studies
- Feeding Sashas EQ lead to a decrease in the circumference of joints swollen by the intra-articular administration of IL-1 consistent with inhibition of increased joint effusion seen in cases of arthritis
- No adverse effects were observed with feeding of Sashas EQ at 5 times the manufactures recommendation for twelve weeks.
Pearson, W., Orth, M.W., Karrow, N.A. and Lindinger, M.I. (2008). Reduced synovial fluid PGE2 production in response to intra-articular IL-1 by horses receiving a dietary nutraceutical and safety of the product over 12-weeks. American Journal of Veterinary Research. In Press.
Key Findings SASHAS EQ Cartilage Explant IN-VITRO study
- Addition of IL-1 to cartilage explant cultures induces inflammation, degradation of cartilage matrix and death of chondrocytes
- Sashas EQ inhibits IL-1 induced inflammation in cartilage explant culture
- Sashas EQ prevents degradation of cartilage and death of chondrocytes induced by IL-1
- Sashas EQ increased cell viability in cartilage explant cultures
- Pharmaceuticals such as indomethacin inhibit inflammation but do not protect against the adverse effects of cartilage degradation and chondrocyte death
Pearson, W., Orth, M.W., Karrow, N.A. and Lindinger, M.I. (2008). Modulation of IL-1-induced inflammation by Sasha's EQ in a cartilage explant model of inflammation. American Journal of Veterinary Research. In Press.
Copyright © 2008 Interpath Pty Ltd 